Iris Röckle Selected Research

CMP- N- acetylneuraminate- poly- alpha- 2,8- sialosyl sialyltransferase

1/2022	Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2.
1/2020	Cell-autonomous impact of polysialic acid-producing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons.
1/2019	Effects of the Genetic Depletion of Polysialyltransferases on the Structure and Connectivity of Interneurons in the Adult Prefrontal Cortex.
1/2017	ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
1/2015	Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
8/2014	A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex.
10/2009	Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity.

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Iris Röckle Research Topics

Disease

7	Schizophrenia (Dementia Praecox) 01/2022 - 10/2009
3	Mental Disorders (Mental Disorder) 01/2022 - 08/2014
2	Autistic Disorder (Autism) 01/2022 - 01/2020
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2022
1	Neoplasms (Cancer) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Demyelinating Diseases (Demyelinating Disease) 01/2017
1	Hydrocephalus (Hydrocephaly) 12/2005

Drug/Important Bio-Agent (IBA)

7	CMP- N- acetylneuraminate- poly- alpha- 2,8- sialosyl sialyltransferaseIBA 01/2022 - 10/2009
6	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA 01/2022 - 12/2005
5	polysialic acidIBA 01/2022 - 10/2009
1	EnzymesIBA 01/2020

Therapy/Procedure

1	Immunomodulation 01/2022